if you are using stock manifolds, don't worry about it. they made them that way and didn't have any leak problems.
if you are going with headers or anything with a thinner flange i would suggest getting good gaskets, use copper permatex on both sides of the gasket, and check the bolts to make sure they are tight after the first couple of heat cycles while everything is settling into place.
if you take the time to do it right you should be fine for a good long time
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