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If you are using IE7, take a look at Tools-> Manage Add Ons.
See if there is anything out of the ordinary in there. If so, disable them. You can also use BHO Demon to look at your browser help objects to see what's up.
In some cases it's best to find the BHO and disable it rather than delete it using a spyware program. A lot of the spyware these days looks for itself in the system registry/DLL list and if it's not there it reinstalls itself. If it's there but disabled you should be fine.
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