You should walk up to max timing based on what plugs say not what the tuner, or engine builder claim.
As far as knock sensors go, I came close to seeing if I could get twin dry sensors installed since my harness has the plug. But decided that it may prove to be more diffucult that worth. The HP forum has a good write up
https://forums.holley.com/showthread...ors-Holley-EFI